University of Plymouth (UoP)
The University of Plymouth is providing expertise on ecotoxicity test methods with fish to the MARINA project.
The lead partner for Plymouth, Professor Richard D. Handy is a fish toxicologist and comparative physiologist with 20+ years experience and is the Director of the Ecotoxicology Research and Innovation Centre at the University of Plymouth.
The centre has a strong theme on nanoscience and key staff for MARINA include Dr Ted Henry and Dr Benjamin Shaw. Our expertise covers ecotoxicity test methods with nanomaterials, dietary uptake of contaminants in fish including methods for making diets containing nanomaterials, and protocols for in vivo exposure from the food, or the water. The laboratory has high expertise on epithelial biology/unstirred layer chemistry, mucus, and uptake mechanisms of nanoparticles. The laboratory is recognised for in vitro organ perfusion techniques for measuring uptake (e.g. gut and gill perfusions in fish, other organs in mammals, developing primary cell cultures from animal tissues) and has an extensive archive of nanopathologies from different animals, and unique expertise on brain pathologies from nanomaterials in fish. The laboratory is currently investigating TiO2, Cu-NPs, Ag-NPs, Silica NPs, SWCNT, and C60. The in vivo work for MARINA is supported by our state-of-the-art aquaria and zebrafish facilities, and also with excellent facilities for particle characterisation (electron microscopy, atomic force microscopy, nanoparticle tracking analysis, single particle ICP-MS, etc). We also have a new state-of-the-art systems biology facility. Our clinical research programme includes cardiotoxicology, genotoxicology, immunotoxicology, and more recently the risks of nanomaterials in dentistry.
Prof. Richard Handy
Ecotoxicology Research & Innovation CentreSchool of Biomedical & Biological Sciences
University of Plymouth
Drake Circus, Plymouth PL4 8AA
Tel.: +44 (0)1752 584630